General GcMAF questions

Macrophages (Greek: big eaters) are cells originating from monocytes, a type of white blood cell found in the body. Macrophages function in both non-specific defense (innate immunity), as well as help, initiate specific defense mechanisms (adaptive immunity) of vertebrate animals.

Their role is to phagocytize (engulf and then digest) cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion.

A macrophage of a mouse stretches its “arms” (pseudopodia) to engulf two particles, possibly pathogens.

GcMAF (Gc Protein derived Macrophage Activating Factor) occurs naturally in our bodies and instructs macrophages to destroy cancerous cells and foreign invaders by activating them.

Macrophages and other phagocytes are found in the following locations in the body:

Main location & Types of phagocytes

macrophages, resident Langerhans cells, dendritic cells, mast cells

Gut and intestinal Peyer’s patches*: macrophages

Lungs*: macrophages, monocytes, mast cells, dendritic cells

Blood: neutrophils, monocytes

Bone marrow: macrophages, monocytes, sinusoidal cells, lining cells

Connective tissue: macrophages, monocytes, dendritic cells, histiocytes

Lymphoid tissue: macrophages, monocytes, dendritic cells

Spleen: macrophages, monocytes, sinusoidal cells

Thymus: macrophages, monocytes

Oral GcMAF(3rd Genration GcMAF)

Oral GcMAF is produced in a similar way to Second Generation GcMAF but uses bovine colostrum instead of serum. It is administered orally and sublingually.

Oral GcMAF is stable with high macrophage phagocytic activity for at least 1 year.
Long-term stability testing is currently being conducted.
To maintain maximum long-term activity we recommend Oral MAF be stored refrigerated

For most serious diseases we recommend Oral GcMAF MAF CAPSULE TRIPLE
Because the site of administration is different so too is the area of macrophage activation and the effect. Its pain-free as no injection and has the same efficacy as the GcMAF injection.

We have observed several common clinical effects from Oral GcMAF, such as:

Improved sleep, more energy; reduced fatigue

Improved digestion, reduced

nocturnal urination

Improved hair regrowth and reduced hair loss due to natural ageing

Improved skin condition & smoothness

Improved control or curing of infectious diseases such as viruses, bacteria and other pathogens

Reduced allergy symptoms, pollinosis and atopy

Oral MAF is a form of GcMAF produced from bovine colostrum which was developed in collaboration with Tokushima University.

Oral MAF is made from bovine colostrum.

Oral GcMAF is produced in GMP facilities in Japan.

Anyone can take Oral GcMAF to stay healthy and fight off disease.

Yes, look into the info tap.

We recommend starting with, MAF Capsules unless the child cannot swallow. Then we recommend MAF powder.

Elimination of wheat and dairy products (mixed or made on the same production line is not a problem). Small amounts are also fine. It is not necessary to be too sensitive to small amounts except for celiac disease. (For example, soy sauce and other condiments). Avoid sugar (brown sugar, white sugar, beet sugar, cane sugar), fructose dextrose solution, artificial sweeteners (aspartame, sucralose, saccharin, etc.). Substitute raw honey, maple syrup, oligosaccharides, monk fruit, organic stevia, etc. if not allergic.
Avoid chemical seasonings, artificial colors, and processed foods.

Yes, there’s no contraindication.

Yes, our clinical trials showed that GcMAF still worked while taking steroids. We still recommend to avoid it if possible.

Even infants can take it.

We only use 1mg of milk protein per capsule, so in most cases, there’s not enough dairy in it to cause sensitivity. However, we do not recommend taking it if you have a severe dairy allergy. If that is the case, we recommend 2nd Generation GcMAF injection.

Frequently asked questions

GcMAF has no side effects .

GcMAF needs 5,000 IU of vitamin D3 daily or a higher dose. Blood levels of vitamin D are often low in many kinds of diseases, such as cancer, HIV AIDS, etc.
Normal vitamin D levels are necessary for GcMAF to work fully.
Ask to have your blood 25 hydroxy-vitamin D as well as calcium levels tested.
If blood calcium levels become elevated, the dose of vitamin D3 may need to be reduced to achieve optimal balance.

Generally, yes. Oral GcMAF can be safely used with a wide variety of other standard treatments and drugs to improve their effectiveness. We refer to this as multimodality integrative medicine. Some therapies for cancer such as chemotherapy will reduce immune activity which will have some impact on GcMAF, however, chemotherapy effectiveness can be increased in combination with GcMAF. Radiation for cancer has a less negative impact on the immune system and the cancer-killing effects help macrophages to target the tumors and destroy them.
In combination with anti-cancer drugs and radiation therapy (radiotherapy) is possible. For maximum effect and benefit from GcMAF, take oral MAF a few days before chemotherapy. Radiation therapy does not have significant effects on Gc-MAF, so both can be used together at any time. In our clinical experience, we have observed significant cancer-killing effects from GcMAF combined with palliative radiotherapy in patients who have had significant prior treatment with chemotherapy. See our Case Reports for more details on this multimodality integrative treatment.

Oral MAF can be taken orally and topically.

One course of Oral MAF GcMAF is usually expected to be for 6 months. Additional courses may be required depending on the stage and type of disease and based on disease symptoms, pathology and progress of improvement. Treatment with GcMAF should be continued as long as necessary while the disease is present. Long-term maintenance doses of GcMAF may be required depending on the type of disease. Maintenance doses are usually once a week or every 2 weeks.

As a general note, macrophage activation is always necessary for the effective functioning of the immune system to stay well and disease-free. GcMAF therapy should continue while there is disease present and for a period after to reduce the chance of recurrence for prevention.

Nagalase testing is not required for GcMAF therapy because macrophage activation is always necessary for the effective functioning of the immune system to destroy cancer cells, bacteria and viruses etc. GcMAF therapy should be continued while there is disease present, regardless of Nagalase status.

Oral MAF macrophage activation therapy is indicated in the treatment of any diseases where there is immune dysfunction or where the immune system is compromised.

please look at the INFO tab at the top of the website for more details

GcMAF can be safely used with a wide variety of drugs and other treatments.

Our GcMAF is tested for macrophage phagocytic activity using mouse macrophages and sheep red blood cells at the University of Tokushima, Japan.

The red blood cells are opsonized which marks them for ingestion and destruction by activated macrophages. Under the microscope, this can be seen as purple areas in the clear cells. From this, we calculate the Phagocytosis (ingestion) Index (PI).

Second Generation GcMAF is made using a new and improved 2nd generation method of Gc-MAF production which is 10-20 times more concentrated and is more active and stable than other GcMAF that is currently available.

Importantly, this much higher concentration GcMAF has been clinically demonstrated to be largely free of any side effects in the great majority of patients and is much more stable because it is resistant to oxidation.