Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) are common and complex neurodevelopmental conditions, that usually start to appear in the first three years of a child's life. Once known as a rare disorder, it is now approaching epidemic, if not in pandemic proportions. Diagnostic criteria for these conditions rely solely on behavioral criteria without consideration for potential biomedical underpinnings. Newer evidence, however, reveals that ASDs is associated with oxidative stress; decreased methylation capacity (gene regulation and detoxification,); limited production of glutathione (antioxidant that protects cells from damage); mitochondrial dysfunction; intestinal dysbiosis; toxic metals burdens, immune dysregulation, characterized by a unique inflammatory bowel disease and immune activation of neuroglial cells (brain inflammation); and ongoing brain hypoperfusion (low blood levels in the brain). Many of these same problems are common features in children with ADHD. These medical conditions have synergistically negative effects on the development, cognition, focus, and attention of affected individuals. These biological abnormalities contribute significantly to the behavioral symptoms intrinsic to these diagnosis.

Inflammation in the Brain and other Immunological disorders discovered in Autism (ASD)

Neuro-inflammation is well-recognized in autism and is part of the etiology of the disorder which is linked to the dysfunction of the immune system. Enhanced inflammatory activity in children with ASD has been found through analysis of pro-inflammatory biomarkers, Interleukins, which are signaling proteins belonging to the cytokine family responsible for regulating the immune system and inflammatory responses.

Children with autism and ADHD tend to have elevated levels of pro-inflammatory cytokines in their blood plasma compared to those without Autism Spectrum Disorder (ASD) or ADHD.

When autistic children are Compared to age-matched typically developing children and children with other developmental disabilities, they exhibit higher levels of plasma cytokines, including IL-1β, IL-6, IL-8, and IL-12p40 in their blood.

Notably, studies have identified two distinctive variations in plasma cytokine among children with autism of varying spectrum severity levels, as determined by the Childhood Autism Rating Scale (CARS) test.

Those with mild autism exhibit higher levels of IL-12p40, while children with moderate and severe autism display elevated levels of tumor necrosis factor-alpha (TNF-α) in their blood.

Certain psychotropic drugs or anticonvulsants prescribed to manage ASD and ADHD symptoms, such as lithium, benzodiazepines, Aripiprazole, Haloperidol, Sertraline, and the atypical antipsychotic clozapine, can elevate inflammatory cytokine levels and has adverse side effects. Unfortunately, they do not provide a cure and are harmful without addressing the root cause of autism. 

so essentially conventional management of autism dose not address the root cause of autism and only attempts to treat the symptoms.

GcMAF treats the root cause of autism and ADHD, it provides a successful recovery.

In addition to the factors mentioned above, various other immunological disorders have been discovered. These include changes in the numbers and functions of T-lymphocyte cells, alterations in gene expression within macrophages, and elevated levels of  nagalase resulting from viral activity which deactivate microglia in the brain, which are crucial for brain health and function.These immunological issues occur alongside abnormalities in the neuro-immune system, oxidative stress (encompassing endoplasmic reticulum stress, reduced methylation capacity, and limited glutathione production), mitochondrial dysfunction, intestinal dysbiosis, toxic metals, and various other immune irregularities.

Furthermore, these altered immune functions are responsible for seizures, sleep disturbances, gastrointestinal problems, lack of food diversity, speech delay, and development delay in children with autism and ADHD.

Importantly, all of these immunological disorders cause alterations in the brain's structure including lack of connectivity among neurons, abnormal impacts on synaptic functions, which are essential for neural communication, as well as brain hypoperfusion (also known as Cerebral hypoperfusion.)

Brain hypoperfusion is when the brain has insufficient blood flow, and it's seen in many parts of the brain in people with autism (ASD) and ADHD. The affected areas include the prefrontal, frontal, temporal, occipital, and parietal cortices, as well as the thalami, basal ganglia, cingulate cortex, caudate nucleus, limbic system (including the hippocampal area), putamen, substantia nigra, cerebellum, and associative cortices.

Research has discovered a significant correlation between the intensity of autism symptoms and reduced blood flow in the brain. In other words, the more severe the symptoms of autism, the lower the blood flow in the brain. It has been suggested that brain and vascular inflammation could be part of the reason for this reduced blood flow.

All These irregularities serve as the foundational reasons behind the emergence and persistence of ADHD and autism spectrum disorder (ASD) and its related pathophysiological mechanism.


Microglia are specialized immune cells found in the central nervous system. They belong to the family of macrophages. microglia play a crucial role in maintaining the health of the brain by being involved in tasks such as inflammation control, removal of foreign substances like pathogen, repairment of neural cells , repairment of the brain and the regulation of individual behavior and movement. Microglia carry out various functions within the brain and are essential contributors to the immune responses of the nervous system. when microglia are not functioning correctly,it can impact neural processes , influencing factors like synapse formation and balance between excitation and inhibition.

GcMAF  immunotherapy supplement is administered to overcome the problem of  immune dysfuction ,including that of normalisation of microglia  functioning and macrophage migration inhibitory factor , which plays an integral role in autism and leads to the commonly observed symptoms .

 GcMAF treatment can normalize these immunological disorders to treat ADHD and autism.

How GcMAF Targets and Addresses Immunological Disorders

  1. Oxidative Stress: GcMAF stops oxidative stress.
  2. Enhancing Methylation Capacity: GcMAF regulates methylation processes, essential for gene regulation and detoxification, and improves cellular health.
  3. Boosting Glutathione Production: GcMAF increases the production of glutathione, a potent antioxidant that protects cells from damage.
  4. Mitochondrial Function: GcMAF's immune-boosting properties aid in maintaining mitochondrial health by assisting in the removal of damaged cells and cellular debris.
  5. Balancing Gut Health: GcMAF induces a balanced immune response in the gut, helping to regulate the microbiome and prevent inflammation associated with dysbiosis.
  6. Detoxification: GcMAF causes macrophages to engulf and digest toxic metals from the body, enhancing overall detoxification capacity.
  7. Immune Regulation: GcMAF effectively regulates all immune responses.
  8. Addressing Inflammatory Bowel Disease (IBD): GcMAF activates a large number of macrophages that reside in the gut to promote healing and prevent inflammation.
  9. Central Nervous System Support: GcMAF activates microglia cells to repair the central nervous system , remove inflammation, remove virus and bacteria present in autistic and ADHD individuals and induce brain connectivity and regeneration.
  10. Brain Hypoperfusion: GcMAF increases blood flow in all parts of the brain. These positive effects translate into improved social behavior, enhanced communication skills, reduced repetitive behaviors, and intellectual advancements for individuals.


For more detailed information about autism, you may refer to the associated research papers below